Super Mario Bros. 3 and Mega Man 2 are both among the greatest games ever made. Hard to pick, but SMB3 feels bigger and more innovative, so I give it to that. Hands down best 2D Mario game, and probably the best Mario game period.

Mamma Mia!

"Rise from your grave" were the first truly audible words I ever heard from a video game. So it's got to be Altered Beast.

The first game I heard speech was Le Manoir de Mortevielle (Mortville Manor in English), which uses synthesised speech - the first game to do so btw.

For me, it was "Blades of Steel" from... Blades of Steel

There were games that had synthesized speed in the early 80's, but I would make fun of how bad they were like Pole Position's "Prepare to qualify."  The first good synthesized speech I heard was in Gauntlet and Gauntlet 2, but even then it was funny that the voice was such a tattletale.

"Yellow Wizard shot the food."
"Dammit Wizard!  I needed that food!"

Yeah, some of the newer pinball games at the time like Black Knight had voice but the first arcade game I can remember was probably Berserk in 1980, then Gorf the next year.  Both were pretty garbled.  The voice in the Star Wars arcade machine a couple of years later was a bit better though.

EDIT:  Oh sh!t, I just saw that you have past threads through the '80s that cover this stuff.

I was just looking when Grand Prix Circuit came out, it was 1988. I thought it was in the 90s oops.

First time I raced on Suzuka and Monza and still do 35 years later! The Grand Prix series was my favorite 'real' racing sim until Gran Turismo launched.

I still have it on a 3'5" floppy somewhere. Played quite a a lot of it, too, but far from being my favorite racing game of the time.

I played GPC at school before I had a computer of my own.

First words I've heard from a game were "Welcome to Populous".