The highest selling Metroid game to date, Dread, sold just over 3 million, so if Prime 4 can exceed that, which I believe it can with the right push, it will be a new record for the series.
Metroid is niche, always has been, probably always will be.
As for Switch, it should have enough gas in the tank to cruise to 155 million at least. getting to 160m is a bit more challenging, but not impossible.
I doubt a price cut will happen given that most things are increasing in price rather than decreasing, but perhaps there's one last revision still in the pipeline similar to the New 2DS XL, Wii Mini, NES/SNES Junior, GBA Micro, etc.