My first game on PS3 was MGS4 Phat (day one 80gb bundle). It died the day I bought Metal Gear Rising. I was installing the game when the system stopped working.
Kinda poetic. Never did finish Rising though I bought a second Super Slim PS3 later on that year (still works).
Also, my Xbox 360 got the RRoD playing Mass Effect and died again playing Mass Effect 2. Crazy. I wound up buying another regular and eventually an S (still have both and they still work).