1. Gears Of War 2
2. Metal Gear Solid 4
3. Resistance 2
4. Fable 2
5. Killzone 2

reistance 2

little big planet

killzone 2 

valkyrie chronicles  (very likely will change when i find out more about it after it launches in japan)

metal gear solid 4

and since i cant keep it at five 

white knight chronicles

gta4

haze

motorstorm pacifica 

I would add Valkyria Chronicles and White Knight Chronicles but I don't know enough about them to warrant a most wanted tag just yet.
I do want a proper RPG for the PS3 this year though, and these two could deliver satisfactory.

1. Starcraft 2 (PC)
2. Left4Dead (PC)
3. Fragile (Wii - may be 09)
4. Valkyria Chronicles (PS3)
5. King's Story (Wii)

if I go down 5 more...

6. Spore (PC)
7. White Knight Chronicles (PS3)
8. Mass Effect (PC)
9. Mario Kart (Wii)
10. Little Big Planet (PS3)

This list changes by the minute and there are about 30 other games I want.....

1. Metal Gear Solid 4 (PS3) 2. Grand Theft Auto IV (360) 3. LittleBigPlanet (PS3) 4. Fallout 3 (PS3 or 360) 5. Left4Dead (360) If Resident Evil 5, Persona 4 and Street Fighter IV come out this year then: 1. Metal Gear Solid 4 (PS3) 2. Grand Theft Auto IV (360) 3. Resident Evil 5 (PS3 or 360) 4. Street Fighter IV (PS3) 5. LittleBigPlanet (PS3) Edit: If top 10 then- 6.Ninja Gaiden II (360) 7. Gears of War 2 (360) 8. Super Street Fighter II Turbo HD Remix (PS3) 9. Tekken 6 (PS3) 10. Too Human (360) I have faith... If Too Human is garbage then Soul Calibur IV (PS3)

Sorry if this seems off-topic, but for those of you listing Fallout, are you actually fans of the franchise? Because most of us fans of the franchise (Rocketpig and I to name a couple) are about ready to murder Bethesda for what they are doing to it. It will barely even resemble what Fallout was before.

I loved Fallout and Fallout 2, right along System Shock games, and this is why I fail at getting my hypemeter up for Fallout 3... By all means, I did like Oblivion (allthough Morrowind kicks its arse gameplay wise and there were tons of promised features that were nowhere to be seen) but the same recipe does not apply to all genres and projects equally well. I think they've blinded themselves to different programming approaches after TES IV finally brought the series into commercial success territory, and that could bite them in the ass right around the time Fallout 3 launches.

As long as they refrain from making an MMO, I won't complain, but I wish they'd keep TES simply, well TES, and the other franchises they're working and will be working on separate. Implementing the same engine or physics (very common among PC games after all) is one thing, copypasting entire conceptual bits is another and should be avoided imo (and in yours as well it seems).

gta IV
mgs 4
Resistance 2
Killzone 2
socom

1. Haze
2. Resistance 2
3. Secret Agent Clank
4. Killzone 2
5. Mario Kart Wii