Ka-pi96 said:
Does it need to explain every death though? It's most likely that the people of Spira would had started out as hunter-gatherers much like the people of Earth. As such they should be able to deal with the odd fiend showing up every now and then without too much trouble.
And there doesn't need to be a paradox. The sending was likely created because the amount of people not moving on naturally when they died and becoming fiends was reaching a dangerous level. Quite possibly as a result of the growing population, and in particular the higher population density as large cities were being created.
Zombies are a good comparison here actually. Ya know, they too are dead people coming back to kill the living. With our current world with the billions of people in it, if a zombie outbreak were to happen we'd be pretty screwed. Go back a few thousand years though and I think it would be much more manageable. There would be much less people for it to infect and it would spread much slower. Because of both of those it would be easier to deal with zombies as they turned, rather than letting it get out of control. I imagine the same could be true of fiends in early Spira. It's only as the population became much larger and widespread that they really became a problem. Probably took awhile for people to realise too. Not something you'd think of straight away, but if people noticed the amount of fiends seemed to increase significantly following a large number of deaths, whether those be due to fighting or disease or whatever else, they probably would have worked out that they were directly related pretty quick. That's when they start looking for a solution... and discover the sending rites.
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Wait, I don't really agree with that last part. If anything, we're more prepared than any other time in history for a standard zombie invasion. Heck, I've always envisioned something like Dead Rising happening, with zombies just merely becoming part of our day-to-day and even featured in TV shows for entertainment. 
Back in the times, a single flu could kill millions of people. Not saying humanity would have gone extinct if zombies had come, but I don't think it's fair to assume they'd fare better then than now. Mankind is deadlier the better technology it possesses. Sure it also says something about their ability to destroy itself, but yeah.
But even if I entertain the idea of "the previous ones defended themselves better", that creates a huge problem when they starting settling down, as their ability to fend off creatures diminished, and there were more as a result. It creates an inexplicable gap, because pretty sure there were some cities before Zanarkand. That or Spira is actually very very young, which could be an answer I suppose.
Think that animals have gone almost extinct as well. There's nothing but fiends and chocobos. It's impossible that mankind could fend off everything that didn't die in peace (heck, the food they gathered?) to get to the point where Zanarkand effectively created the Sending. Or I just can't see it.
That assuming animals did vanish as a result of becoming fiends. But considering the presence of passive chocobos or shoopufs, it's plausible, since there's nothing else.