48 hint: two plumbers and a turtle take a trip to a nearby kingdom to get someone's voice back
47 hint: you play as twins in this strategy game with perma death.
This should be fine :)

48 is superstar saga

I'll go ahead and post my 50 and 49.

50 - You travel around levels riding a magic carper, get magic spells from red pots, build a castle, kill monsters to get orange mana balls, and kill the other enemy carpet riders. When you get enough mana, you beat the stage and move on to the next one.

49 - It's a zombie survival game where you try to run to safety, while fending off zombies. However, if you try to solo it, you will die.

Nice try, but not that one

Left 4 Dead?

Almoooost.

2?

#50 Game Description: This spin-off series makes it's debut on a Sony platform, where the next (and final) 2 installments moved over to Nintendo handhelds. This is the 2nd game that made it's first debut on the GBA

Game hint: Anime Hairdo

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#49 Game Description: This is yet another spin-off game where the developers used the IP from another company. This game merges many of the characters from past titles within the franchise, though many are only obtainable through DLC

Game hint: The Guardian was split into 2 characters, the light which joins you near the beginning, and the dark which is the antagonist

Ding diing

49- Mega Man 2


Easily the best one of the classic MM games. The level design is top-notch, the game is dickish in just a few spots, the soundtrack is amazing and the Metal Blade is the best thing that has ever happened in the Mega Man universe.

Hint for 48: It's the most popular game of the console it was released on. Some people will never move on from it.