Either Zelda or Persona 5, but I'm not 100% certain either will come in 2016. I'd give Persona 5 about a 75% chance and Zelda a 50% chance of coming out next year.
I don't think Uncharted 4 will score as highly, because, regardless of how good it is as an Uncharted game, it will be seen as a step back from The Last of Us. That said, if neither of the two aforementioned come out next year, it will probably score the highest.
Still, games like Gears of War and Uncharted are going out of fashion.

Zelda for sure.

Persona 5 with a 96... too optimistic??

That gap tho

Surely this is between Zelda and Uncharted. I don't really see those other choices having any sort of realistic chance unless something unexpected happens. Remember, for the big primary mainline console Zelda's, '95' is mediocre.

Mass effect, zelda or Quantum Break.

Zelda or Uncharted. Maybe DSIII but I'd assume not since we're currently at Souls overload and that SHOULD factor into reviews. Whether it does or not who knows.

Zelda

I feel the top three are going to be:
1. Zelda
2. Persona
3. Uncharted

Persona 5 should be listed. It has a higher chance than half of the games listed at getting the highest. Golden has a 93 meta.