If i tell you i have EASILY played Streets of Rage 2 for WELL OVER 100 hours (and its only a 45 minute long game) that pretty much explains why it would be impossible for me to remember even half the games i have played for over 100 hours.
Noteable games for this gen with over 100 hours would be....
Dead Rising (hey, surviving 7 days without dying takes 16+ hours alone)
Virtua Tennis 3 (close to 1000 online matches in that game, plus world tour)
Sonic & All-Stars Racing: Transformed (career plus tonnes of multiplayer races)
Resident Evil Revelations (100 hours on BOTH 3DS and 360)
Resident Evil: The Mercenaries 3D (over 200 hours last time i checked)
Gears of War 3.
Ninja Gaiden 2.
Ninja Gaiden Sigma 2.
WWE Smackdown vs. Raw 2007.
Ridge Racer 6.
Project Gotham Racing 3.
Forza Motorsport 3.
PDC World Championship Darts 2008.
Left 4 Dead 1 & 2.
i give up, too many.