I saw Tbone made a thread about 10m sellers but I feel like 5m is a more interesting total to discuss. Games can be exclusive or multiplat. For reference here are the games that sold over 5m on previous Nintendo consoles

NES                                              SNES

1. Super Mario Bros-40.24      1. Super Mario World-20.61

2. Duck Hunt-28.31                   2. Super Mario All Stars-10.55

3.Super Mario Bros 3-17.28    3. Donkey Kong Country-9.30

4.Super Mario Bros 2-7.46      4. Super Mario Kart-8.76

5.Legend of Zelda-6.51            5. Street Fighter II-6.30

6. Tetris-5.58                             6. Donkey Kong Country 2

N64                                              Gamecube

1. Super Mario 64-11.89         1. Super Smash Bros Melee-7.07

2. Mario Kart 64-9.87              2. Mario Kart Double Dash-6.95

3. Goldeneye 007-8.09            3. Super Mario Sunshine-6.31

4. Ocarina of Time-7.60

5. Super Smash Bros-5.55

6. Pokemon Stadium-5.45

7. Donkey Kong 64-5.27

Wii                                                             11. Just Dance 2-9.25

1. Wii Sports-81.42                                12. Wii Party-8.06

2. Mario Kart Wii-33.84                         13. Mario Party 8-7.93

3. Wii Sports Resort-31.83                   14. Mario & Sonic Olympics-7.89

4. Wii Play-28.74                                    15. Super Mario Galaxy 2-7.07

5. New Super Mario Bros Wii-26.83    16. Just Dance-6.98

6. Wii Fit-22.65                                        17. Twilight Princess-6.82

7. Wii Fit Plus-21.30                               18. Just Dance-6.56

8. Super Smash Bros Brawl-11.80      19. Zumba Fitness-6.41

9. Super Mario Galaxy-10.86                20. Donkey Kong Country Returns-5.94

10. Just Dance 3-9.73                            21. Lego Star Wars-5.12

My predictions

1. Nintendo Land-its already halfway there and while its no longer part of the main bundle, it did get a price drop to $29.99 and could very well be bundled again in the future.

2. New Super Mario Bros U-almost halfway there and is now bundled. Every mainline 2D Mario on consoles has passed the 5 million mark and I see no reason why it wont this time as well.

3. Super Mario 3D World-The worst selling 3D Mario game sold 6.31m on an install base of 21.74m so as long as Wii U sells at 15-18m this game should pass 5m.

4. Donkey Kong Country Tropical Freeze-Of the 5 mainline Donkey Kong games released in the past 20 years, 4 of them have passed 5m. The only one that didnt was DKC3 and that was the 3rd DKC released in as many years, didnt feature Donkey Kong or Diddy Kong and came out after next gen was in full swing so id say its very likey Tropical Freeze passes the mark.

5. Mario Kart 8-Every Mario Kart game has passed 5m and the last 3 entries have sold just under 1/3 the install base so as long as Wii U sells 15-18m, Mario Kart should pass 5m.

6. Super Smash Bros U-Once again every Smash Bros game has passed 5m and even tho this one will also be available on 3DS I still see the series being primarily a console game. I believe it will pass 5m.

7. Zelda U-Legend of Zelda, Ocarina of Time, Twilight Princess all passed 5m and Link to the Past and Wind Waker came very close. I think this one has a strong chance of making it.

8. Wii Sports Club-if this game gets a retail version with the most popular games of Wii Sports and Sports Resort then I believe it will pass 5m.

1. Mario Kart 8-12m

2. New Super Mario Bros U-10.5m

3. Super Mario 3D World-8.5m

4. Super Smash Bros U-8m

5. Nintendo Land-7.5m

6. Donkey Kong Tropical Freeze-6m

7. Legend of Zelda U-5.5m

Exclusive:
Mario Kart 8
3D World
Smash 4
Nintendo Land
Donkey Kong
Zeld U

Multiplat:
None

Lifetime? Any "Mario" game, probably the new Zelda and Smash Bros.

Basically the same list as mine and in the same order lol

Mario kart
Wii sports 3
Smash bros
Donkey Kong

Why no NSMBU or 3D World?