No good games are announced on E3 any more, but Legacy Of Kain , though I doubt that is going to be announced since they're working on thief at the moment.

Wii U

Mario 3D
Smash Bros (with Mega Man)
Bayonetta 2 for 2013
Wonderful 101
Sonic The Lost World (different from 3DS version)
New Retro IP
New Wii Sportsish title
Xenoblade 2
Pokemon Z (Compliment to X and Y with a heavy focus on online but no quite an MMO)
Mega Man U (collaboration with Capcom)

3DS

Mega Man Legends 3 (maybe not so realistic :( )
Layton vs Phoenix Localization
Phoenix Wright 5
New 3D Kirby platformer
New Star Fox game (I think 3DS makes more sense for the franchise ATM)

Wii U:

3D Mario (rumoured coop *-*)
Bayonetta 2
NEW Wii U Zelda!!!
"Xenoblade 2"
Retro's Game
Smash Bros.
Wind Waker HD
SMT x FE
Mistwalker's Game
Mario Kart
Sonic Lost world (looks fantastic)
the rumoured Wii U exclusive which will get more hate then Bayonetta 2

3DS:

ALttP 2 (of course)
Pokemon (the first Pokemon I'm interested in since Gen 1)
Yoshi's Island 3DS
Mario Golf

PS4:

Deep Down

3rd Party:

BF 4 Multiplayer Footage (not just an updated BF 3, wanna see something special never seen in a FPS MP before)
Red Dead Remption 2!!!
Elder Scrolls 6 (has to improve dramatically over Skyrim, Skyrim was mehh)

EDIT: I forgot Earhtbound U and Dragon Age 3