Mass Effect is number one for me!!!

Runner-ups go to Dragon Age, Dead Space and Uncharted.

Uncharted, all three games are amazing.

This is easy for me! Definitely Mass Effect!

1) Assassin's Creed
2) Souls franchise
3) Uncharted
4) Gears of War
5) Mass Effect

The souls series (dark/Demon's)

number 1 would be bioshock due to the first game alone. If bioshock infinite comes even close to matching the first one bioshock will probably be one of the best ips ever not just from this gen. Bioshock 2 was a big dissappointment only because bioshock raised the bar so high. I feel like if it wasn't compared to the original it would be a good game on its own rights. 

number 2 would be professor layton. Its amazing how fun level 5 managed to make a simple puzzle game with a quirky story. 

number 3 valkyria chronicles because I love stratagy games.

I must have weird taste in tps games. Don't really like any of the very popular ones. I think gears of war, uncharted, and mass effect are extremely overrated, but I loved dead space 1/2 and vanquish. Dead space would be pretty close to my favorite new ip. Sadly vanquish will never get a sequel due to its horrible sales.

1. Bioshock!
2. Uncharted
3. ... and Bioshock

oh can only pick up one franchise？
so sorry assassination creed，it must be uncharted

Mass Effect. No competition.

So Many Good ones, for me Uncharted... but Mass Effect 3 may change that.