The megaton will be that they will show so many hardcore Kinect games, that the only reasonable explanation anyone can give for why they don't want Kinect is "I AM PROGRAMMED TO HATE MOTION CONTROLS!".

Well their main focus is probably going to be on Kinect with a large majority of the show simply showing off and announcing new games for the peripheral, so the megaton, to them at least, should come in a Kinect game announcement.  My guess, though, the big announcement will be Halo related.  I'm just hoping it isn't Halo and Kinect related as I would scream haha.  

Other possibilities are the new Lionhead Studios games, first showing of the Xbox 3, or a pricedrop of Kinect, 360, or both.  I'd say of those 4, at least one should happen.  Be pretty cool if all of it happened though... well not the Halo Kinect part.  No literally, I would scream.

I think their megaton will be giving away a free hooker with the purchase of every 360! 

Oh god no.  No no no no no no.  Maybe another Kameo game or they can keep going with Viva Pinata, but I don't know if I can bare to see more of the franchises come back to life with them.  Maybe Conker, but I would be skeptical till the end haha.  I know there are people that like Perfect Dark Zero and Banjo Kazooie: Nuts and Bolts, but for me it was not pretty.  I guess another shot at the series should be allowed, but it'll be rough haha.

Final Fantasy 7 Remake Confirmed.

I'm with you on the Halo thing.  Nothing against the series but Bunji isn't there anymore--and even if they were, there's been too much Halo this gen.

Speaking of Sega, here is a game that will be revealed at E3: http://360informer.com/2011/06/aliens-colonial-marines-resurfaces/#more-1392

um ....... random much

Modern Warfare 3 on the Kinect.