Ok, I feel stupid saying this, but it was in Starcraft 2 in the arcade game. I really really really wanted to get an insanely high score in the game, so every night, I'd play it a couple of times and really have no real successes, and be left with a super sore wrist due to pushing the shoot button as fast as I could throughout the whole thing. Finally, after a week or so, and easily over 100, if not 200 attempts of no luck, I got to level 20 (give or take 1...I can't seem to remember). My final score was like 1,1XX,XXX.
Despite pausing once (for about 5 minutes) in order to save my poor poor wrist, I thought it was going to fall off after pushing space for over 2 hours.
While getting to the level itself wasn't too terribly hard, as it is just the same 3 levels over and over, getting slightly harder each time, dealing with my wrist feeling extreme pain for as long as I did was brutal to me. I just felt like giving up and dying so many times so I could just stop destroying my wrist, but I wanted 1 million soooooo badly.
Even more brutal was when afterwards, I discovered there is absolutely nowhere you can look that says what your high score in the game was, only a trophy for reaching a couple of scores...what kind of arcade game doesn't show you your high score!!!!!!!!