After the sneakpeak at the VGAs you should all want to play: Prototype, a sand-box style game in New York where you embrace others powers, and become some sort of superhuman freak, it looks amazing.
Best part: It comes from the same development house as Incredible Hulk: Ultimate Destruction, a studio that knows how to make a great open world desctruction styled game!
Another preview from the VGAs, an open world hybrd of fps and rpg with a mad max styled universe.
Best part: 500,000 guns.
an impressive new IP from Lucasarts, a shooter with an interesting new twist.
Best part: Terra deforming grenades
An action/adventure game where the world of rock/metal is a real sort of prehistoric world(hard to explain) Jack Black is involved
Best: Tim Schafer is making it.(Day of the Tentacle and Full Throttle, and Pychonauts)
LOST: THE GAME
Graphics look nice, the show is great, so a shot at playing in the world certainly is entertaining. Ubisoft Montreal has a lot of good games under their belt, hopefully this will be another one.
Best Part: We don't get alot of adventure games.
LEFT 4 DEAD
Impressive looking zombie shooter. Valve is publishing the title.
Best part: Should take co-op gameplay to the next level.
TAKEN OFF THE LIST: HEIST
Of course there is more out there or you might disagree, feel free to add!