Uncharted, Valkyria Chronicles and inFamous.

Here goes loool

PS3: Uncharted, LBP, Mod Nation Racers, Heavy Rain, Infamous, Demon Souls, Dragon Age, Valkyria Chronicles:):)

F.E.A.R. was on PC first, Left for dead is on PC to (I will leave Gears alone but the first is on PC) Mirror's Edge is multi platform so is Braid and BlazeBlue.

@ Cross-X & snf Mass Effect is Multi plat (PC) 

i wouldn't nag but you guys made a point of listing platforms and even multi plat...

Anyhoo personally 

S.T.A.L.K.E.R.

The World Ends With You

Portal

Mount & Blade

Borderlands

Legue of Legends (LoL)

and thats all I can think of AtM 

P.S. Batman isn't really a new ip

FEAR  is not new, more of a PC Game.

forgeting motorstorm

As many other users have said: No More Heroes

OP Updated.

Also just remembered Shadow Complex, it's a highly acclaimed XBL Game.

I'd say Zangeki's noteworthy, even if we're not getting it. :/

Anyway, new Nintendo IP this gen... bolded games were pretty noteworthy either critically or commercially (or both!)...

• Another Code / Trace Memory
• Aqua Living
• Archaic Sealed Heat
• Art Academy
• Art Style
• Aura-Aura Climber
• Big Brain Academy
• Bonsai Barber
• Brain-Age / Training (and derivatives like Math / English / Vision / etc Training games)
• Captain Rainbow
• Clubhouse Games
• Cooking Navi / Guide
• Disaster
• Eco Shooter
• Electroplankton
• Elite Beat Agents / Ouendan 
• Endless Ocean
• Flipnote Studio / Moving Memo Pad
• Fossil Fighters
• Hotel Dusk
• Jam with the Band
• Jet Impulse
• Kappa Road
• Kensax
• Link N' Launch
• Looksley's Lineup
• Maboshi's Arcade / Sujin Taisen
• Master of Illusion
• Metal Torrent
• Nintendogs
• PictureBook Games
• Pinball Pulse
• Photo Dojo
•  Polarium
• Project Hacker
• Rhythm Heaven / Paradise
• Rock N' Roll Climber
• Slide Adventure Mag Kid
• Soma Bringer
• Spotto!
• Starship Defense / Patrol
• Style Savvy / Girl's Mode
• Super Control Mecha MG
• Takt of Magic
• Tomodachi Collection
• Touch Panic
• Trajectile / Reflect Missle
• True Swing Golf / DS Golf
• Theta
• Walk with Me / Personal Trainer Walking
• Wii Sports / Play / Fit / etc
• You, Me and the Cubes
• Zangeki no Reginliev

To OP: Trauma Center started on DS!

Anyway, IPs I'd add...

360: Blue Dragon, The Last Remnant, Earth Defense Force (in America at least)

Wii: Endless Ocean

DS: Etrian Odyssey, Retro Game Challenge, Rhythm Heaven, Contact, Starship Command

multi: Bayonetta, Nier

I've actually noticed several games listed in the thread that aren't *really* new IPs... and actually I listed one myself! :x

Batman: Arkham Asylum: Uh... really?  lol!

Shadow Complex: Based on Orson Scott Card's The Hidden Empire series of novels.

Portal: Retconned into a Half-Life spinoff. :/

Super Princess Peach: Mario spinoff.

Retro Game Challenge: Based on Game Center CX television series by FujiTV.  Damn!

Xbox 360: Alan Wake, Gears of War, Deadly Premonition, Ninja Blade, Mass Effect, 

PS3: Demon's Souls

Dead Space