In no particular order:

1. Twilight Princess
2. No More Heroes
3. Silent Hill: Shattered Memories
4. Metroid Prime Trilogy
5. Super Smash Bros Brawl

Well, I have just finished Crystal Bearers and I have to move it up a spot. Great ending to a very fine game. It's a shame that the reviewers didn't give it a chance. But, I am hoping for another one.

Thanks for posting!

Very difficult to just name 5 but here goes, in no particular order:

1. Pro Evo 2010
2. Metroid Prime Trilogy
3. Red Steel 2
4. Tiger Woods 2010
5. de Blob

Great idea for a thread, kind of a modern day Desert Island Discs. :oD

1 - The Legend of Zelda Twilight Princess
2 - Super Mario Galaxy
3 - New Super Mario Bros Wii
4 - The Beatles Rockband
5 - Rune Factory Frontier

Radiant Dawn and Wii Sports Resort are great too

1. Twilight Princess
2. Mario Galaxy
3. Mario Kart Wii
4. Super Smash Bros. Brawl
5. Resident Evil 4

1. Metroid Prime Trilogy (Didnt have a gamecube so... playing metroid prime 1 and 2 with wii controls was absolutely incredible).

2. Tatsunoko vs Capcom (80 hours spent on it so far, great fighting game).

3. Little King Story (So unique).

4. Fire Emblem: Radiant Dawn (One of the most difficult games I have played in my life).

5. Super Mario Galaxy (whoa... I didnt believe it, but yes... is one of the best games on the wii. So creative).

Honorable mentions:

New Super Mario Bros Wii (multiplayer FTW).

Punch Out! (Awesome, just awesome).

Muramasa (incredible 2d experience).

Madworld (incredible soundtrack, short but fun).

Red Steel 2 (nice sword fighting).

1. Mario Kart Wii

2. Super Mario Galaxy

3. The Legend of Zelda: Twilight Princess

4. Super Smash Brothers Brawl

5. New Super Mario Brothers Wii

1) Rune Factory Frontier
2) World of Goo
3) Super Mario Galaxy
4) No More Heroes
5) Metroid Prime Trilogy

Its difficult to pick my five favorite games the Wii has to offer.

1) Wii Sports Resort
2) Animal Crossing : City Folk
3) Punch-Out!
4) Speed Racer
5) Endless Ocean : Blue World

Honorable Mentions:
Fragile Dreams : Farewell Ruins Of The Moon
Excitebots Trick Racing
How To Train Your Dragon (Fighting Dragons = Awesome)
Band Hero

Hmm, no easy task!

1. Super Mario Galaxy
2. Metroid Prime Trilogy
3. Super Smash Bros. Brawl
4. Mario Kart Wii
5. Silent Hill: Shattered Memories