I think one or both of Starfox and Pikmin is pretty much assured. Hopefully for the end of the year, but likely will be a pre-rendered teaser with a fist half 2011 release. That being said, I'm gonna go with some less likely ones.

Pokemon Wii MMO
F-Zero Wii
Pilotwings Wii

One of those will be announced alongside either Starfox or Pikmin for first half 2011, similar to the Galaxy 2/Other M announcement last year.

don't know... surprise me Nintendo thats all i gotta say

You do know that Zelda is confirmed to be at E3 with a playable demo?

Hmm... I'm seeing talk for a few of the new game sales, like MHTri, Mario Galaxy 2, and maybe even Other M. I also see sales for their systems, with a focus on the DSi XL. Possibly talk of NSMBWii closing in on (or even reaching?) 20 million shipped copies. I'm also hoping for dates for a few of the other titles, like Xenoblade, Last Story, and maybe a trailer and a generic 2011 release date for DQX. I think a trailer and hands-on gameplay of Zelda Wii is almost a given, as is a demo of the Vitality sensor. Black Wii is also finally coming to America.

There is one more I can see, though I think it's too hard to predict- that is, DS2. First, there will not be a Wii 2. Why announce a new system before you even release accessories for a current one? But DS2, well... that's tougher. If rumors start to come out in full force for a PSP2, I think Nintendo will announce a DS2 for release next year. If there are no rumors, I think Nintendo will have it anyway, just in case Sony goes before them in the conference and managed to keep PSP2 hidden. (Though given Sony's record, I don't see this.) If there is a good chance of an announcement, I don't see Nintendo wanting to let Sony steal the portable market hype. However, if Sony doesn't say a peep, I don't think Nintendo will either.

They can't talk sales for Other M, it won't be released by then. Pretty sure E3 is mid-June this year, but that still precedes Other M by two weeks or so.

Well most things I'd think of have been said already, so all that is left for me to say is:

Dragon Quest VII or VIII remake on Wii (just like they remade IV and V on the DS before IX, to make the series more popular)

1. Vitality sensor + games
2. Zelda Wii
3. Line Attack Heroes
4. New Hardware- DS2

For sure:
- New Zelda
- Vitality sensor's software
- New Golden Sun

Probable:
- New Pikmin
- New Mario Party
- Unexpected game

Perhaps:
- DS' sucessor

i would cry right there.tears and boogers.