Japan doesn't like Zelda.

Edit: It seems Japanese don't like Moder Zelda. Zelda , Zelda II, A link to the Past and Ocarina of time all sold really good in Japan. Special attention to Zelda I and II.

PS3 - GT5, easily. Assuming it isn't delayed to 2011. It could easily do close to 2 million first week and if its released in Fall then 6 million by years end. My prediction anyways.

360 - Halo Reach. It has Halo in the title.

Wii - Wii Fit 3, just kidding. Probably Galaxy 2. It sould do nicely.

Don't know about handhelds, but:

PC - StarCraft II, if released this year.

PS3 - Gran Turismo 5, if released this year.

Wii - Super Mario Galaxy 2.

Xbox 360 - Halo: Reach.

PS3 - Call of Duty 7 (its so front loaded)

Xbox 360 Halo: Reach

Wii - SMG 2 (my guess is Nintendomination if its not)