Second Game is the Best

[Bofferbrauer2]

Here's a couple of PC games:

The Settlers 2
Day of the Tentacle (Maniac Mansion 2)
Monkey Island 2: LeChuck's Revenge
Master of Orion 2
Diablo 2
Fallout 2
Drakensang: The River of Time
Gobliins 2
Jagged Alliance 2
Populous 2
Star Wars: Knights of the Old Republic 2: The Sith Lords
Wasteland 2
WarCraft 2
Command & Conquer: Red Alert
Theme Hospital (Theme park was the first in the series)
Magic carpet 2
Dungeon Siege 2
System Shock 2
Half-Life 2

And a few console titles:

Megaman 2
Earthbound
Super Metroid

Finally, probably very unpopular opinion: Zelda 2: The Adventure of Link. Still my favorite of the series.