It's hard to say which was my first game in HD as I was a PC gamer with a CRT monitor that could do 1024p? But which was the first game in that resolution I can't tell, possibly Tomb Raider 2? Then in 2008 I bought my first widescreen 1080p monitor.

Deus Ex (2000) - a game that pushes the boundaries of what the video game medium is capable of to a degree unmatched to this very day.
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