I don't know of anything that will completely shut down my interest, but there are things that are red flags.
For example, if it's not a genre I enjoy, I probably won't pay much attention to it: First Person games (not including light gun or IR pointer games, which I do like), dungeon crawlers, sports games, fighting games - and some of these I used to enjoy, but not anymore. It doesn't mean it's an absolute "fuck no!" But not a likely purchase.
I describe myself as a little dose of toxic masculinity.