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LegitHyperbole said:

The worst thing about this game so far is trying to choose what character gets sent back to camp. I really hope the party members you axe from the group tag along the whole way even if you're not using them. They're all so interesting right out the gate.

Best advice is to rotate them. Some of them unlock unique dialogues in some parts of the game. If you really feel like benching someone, I think Karlach is your best choice. She has few utility outside combat and her story is most basic and with the least amount of unique dialogue/interactions 

Astarion is good for rogue utility, and Gale is great because he's your only Inteligence unit (unless your main character is also a Wizard). You can't go wrong with Laezel either, great fight unit and very important story overall

In act 2 keep Shadowheart in your party the most you can. She's almost the game deuteragonist in part 2