Personally - I’d say Xenoblade.
But I also see Xenoblade as the third iteration of the “Xeno” branding within the Xeno-franchise; branding switches with the move to different parent companies. And in another way, the child franchise of Final Fantasy 6 and Chrono Trigger given the first game began as a sequel to both of those and absorbed and advanced on core elements: Mechs, a divine power source, an alien god who will bring the apocalypse, etc…: Magitek Armour = Gears, Lavos and Goddess Triad = Deus, the source of magic for Espers and Magitek Armour = Slave generators, the day of Lavos = awakening of Deus into Xenogears, and those evolved into successor versions in Xenosaga and Xenoblade. But FF6 and Chrono Trigger were both headed up by Kitase with Takahashi has one of the primary creatives, while Takahashi himself created and ran Xenogears, Xenosaga (well, the first game, the second and third had him pulled off, and they continued from his notes, but went in strange directions), and Xenoblade
Objectively - Wii Sports, it was the biggest killer app of the generation. And for something that was derided by its jealous critics as a “fad” it certainly spawned a lot of successor type games in terms of software collections and motion controls - from Wii, to Switch, to Xbox Kinect and PS3 Move, to VR. Its most recent sequel, Switch Sports, sold 13 million + units, Ring Fit Adventure (the sequel to the spinoff, Wii Fit) has sold over 15 million, 28+ million for two titles making it one of the most successful franchises this generation.
I describe myself as a little dose of toxic masculinity.
