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A lot of the time it depends on the kind of game you want to make.

Take Xbox vs Wii. They each have advantages over the other in different areas, so both are capable of things that the other is not.

A game like Doom 3 or Chronicles of Riddick that's heavy on vertex shaders and shadowing works better on the Xbox, but a game like Mario Galaxy or Jet Rocket that leans heavily on the TEV's multitexturing capabilities works better on Wii.

Similarly, a game that leans heavily on the Xbox 360's eDRAM bandwidth to spam a lot of full res alpha effects would bring the PS3 to its knees, while by contrast a game that leverages the Cell for post-processing and physics would be hard to replicate on 360.