If the Switch 2 is backwards compatible, we could immediately discard Switch ports. If not, we'll see Metroid 4 and LoZ TotK as launch titles.
As for new games, if we're assuming one big release per month, like they did with the Switch, we will probably see MK9, Mario Odyssey 2, Pokken 2, Splatoon 4 and maybe a remake of a Zelda title.