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The real question is which main attraction are you talking about? You could argue that last E3 Nintendo had 3 main attractions, Metroid Prime 3 for the "Core" gamer, Wii Fit for the "Blue-Ocean" gamer, and Super Mario Galaxy for everyone.

This year I would expect Kid Icarus or Disaster: Day of Crysis to be the main attraction for "Core" gamers, Wii Music or something unexpected to be for the "Blue-Ocean" gamer, and Animal Crossing or Pikmin 3 to cover everyone.