I think trying to encompass the ovarall universe in one game would be waaay too much, and if they did want to make a game set in the cosmere it should focus on one world and telling a story within that.
I think The Stormlight Archieves makes the most sense as a very unique and fleshed out world, but it could also be cool to play as a Mistborn in their world ofc. Either of those games could be amazing if they manage to really capture the world and tell a good story within in, while not neglecting the gameplay either, but needless to that's an extremely ambitious undertaking.
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