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Full playthroughs would be Civilization for sure.
Full campaign playthroughs goes to Dune 2.
Non strategy would be Journey, but that's quite short and technically not single player.
Actually I've probably driven Outrun from start to finish quite a few more times.
I've replayed Wolfenstein 3D and Doom quite a few times as well back in the past.

New games are simply too long to replay. I still haven't finished Horizon FW, still loving it. But zero incentive to ever start another 3 month play through lol.

Of course if it counts, Tetris wins over all else.