Since others are commenting about their picks, I guess I'll do mine too:
#50 - Wii Sports Resort - I was late to the Wii craze and my Wii came packed with both Wii Sports and Wii Sports Resort. I hadn't had a console since the PS2 but my wife insisted on getting a Wii for our kids (2 and 4 at the time). I fondly remember playing sword fighting with my kids and that was among their first video game experiences. Wii Sports was a huge reason for the Wii's success, but I always felt Resort was the better game, so that one takes the spot in the top 50.
#49 - Castlevania II: Simon's Quest - I know, I know...Castlevania II?? Am I crazy? Well, I remember when this game came out I was getting Nintendo Power magazine, and without those articles about this game I'd never rate it this high. But having the magazine with the game, with its maps and tips, made it much easier to understand, and I fell in love with it. My favorite part was the upgradable whip...the flame whip ruled!
Switch: SW-3707-5131-3911
XBox: Kenjabish