Alright, I finally had some time to think of some hints, so let's start with these.
#50: The asylum thing wasn't quite working, so instead we walled off a part of the city to keep them in instead.
#49: A very angry man becomes slightly less angry and learns to get along with others.
#48: A potato can generate just barely enough power.
#47: The most recent big cross-over punch-up in this series.
#46: Before a new game came out in the series just a while ago, this game from 27 years ago was the last 2D home console entry in the series.