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Resident Evil 4 - the island. Not sure how I love this game so much, considering how much of the island I hate. Particularly everything from the Krauser knife / boss fight up through the two rooms after where the helicopter helps you clear out the waves of enemies. The boss in the cage is the only bit that comes to mind that I like.

Twilight Princess - that temple in the Sky.

Super Mario Sunshine - that Watermelon Festival. And Eely Mouth Dentist. I dread both every time.

Tomb Raider III - I really enjoy this game, but there's so many sections that are torture that I'm not sure where to begin. Madubu Gorge and a lot of London immediately spring to mind.

Banjo Kazooie - Rusty Bucket Bay. Guaranteed to die and lose all my notes.