Coronavirus (COVID-19) Discussion Thread

[haxxiy]

Vaccine antibody titers from an upcoming pre-print indicate that the Indian variant sees just a moderate decrease in neutralization. The two amino acid changes together actually confer less antibody escape than the change to glutamate in the 484 residue on its own (which already had a lesser loss than the change to lysine in that position). That just goes to show that looking at mutations in RBD residues alone is meaningless since they will interact in unpredictable ways when actually combined.