Symmetrical or asymmetrical analogue sticks?

[GrahfsLament]

I, too, have to go with symmetrical sticks, specifically the DualShock layout (as opposed to the Wii U Pro Controller). My thumbs naturally rest in the place of the DualShock's analog sticks (1-3 more than 4). The asymmetrical sticks of the Xbox's Controller S (can't speak for the Duke), 360 controller, and the One controller all hurt my wrists (mostly my left, but somewhat my right as well) something fierce, while the GameCube controller just hurt my hands generally. I can say that, despite the original Xbox being my favorite system of its generation, I actually had to hook up a DualShock 1 (not 2 because all face buttons were analog on the DualShock 2) to my original Xbox with an adapter in order to beat the last boss in Ninja Gaiden Black on the hardest difficulty. I ended up buying a similar adapter for my GameCube and never went back after that. I can't really speak to any other asymmetrical layouts off the top of my head.

I'll also add that though my thumbs naturally rest on the DualShock's sticks, I still use my thumbs to push the D-Pad and face buttons. Manlytears's photo reminds me of playing Monster Hunter Freedom Unite on the PlayStation Portable :D. It can definitely be effective, but I personally was thrilled when I was able to download MHFU to my Vita and use that second analog stick instead.