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Immersiveunreality said:

Always having to endure that because your brains functions differently makes you stronger when other things suddenly strike you,being an autist an having ocd myself i can tell you that my biggest hurdle is living with myself.

I think that everybody is their own worst enemy in one way or another.  We're hard on ourselves,  feel like we fail to live up to our own expectations, don't give ourselves credit for our accomplishments, think our negatives are a bigger deal than they are, while overlooking our positives, etc.  Or, we get in our own heads about stuff that just isn't a big deal, build it up into something terrible. 

These specifics may not apply to everyone all the time.  But, if one thinks most of them don't apply to them, then they're exhibiting a lack of humility that is also a way many of us stand in our own way.  

Anyway, not trying to minimize anyone's struggles.  Just sayin', for most of us, the biggest hurdle is ourself, in one way or another.