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I'd prefer a mouse. More people have USB mice than Wiimotes.

That said, I don't find the Wiimote a lot more effective than the analog sticks. It depends on the game for both, really. CoD4 was really good, but Dark Sector was too floaty. For the Wiimote, sensitvity matters and the Wiimote doesn't act as a gun, it acts as a less sensitive mouse. I had no problem playing MoH:H2 and MP3 then going back to sticks.