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If i was going to play RE5 i would feel the 360/PS3 controller would do the job best. The wii-mote is good for games where you just need to point or wave your arms like elebits or wii sports. The wii-mote takes away the camera from the user and this is very bad in my books. SMG would of also benefited from the use of the PS3 or 360 controller. The nunchuck also does not fit my hand right, the stick feels very bad and the two front buttons are very hard to press in fast paced games.