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Xxain said:

Assassin's Creed Odyssey.

The very first moral choice you get to make is wether to kill a sick family that isn't recovering. They looked fine and they said they were getting better, so I killed their would be killers and they were free. Turns out they were sick with the Plague of Athens. Now the intro Island is covered in a eerily thick fog with dead bodies littering the towns and villages. Perpetual rain as well. I could have stopped the Plague of Athens from spreading, now it will effect the rest of the games regions by end game.

This. I didn't expect it to have much of an actual effect, let alone one that lasts through the entire game. It had better not be the only choice like that in the game because now I'm expecting others and haven't found any so far (although I'm not very far into the game yet, so there's probably still tons of time).