Dead Rising; though that one got a port for the Wii, but both games were fundamentally different in nature.

If that one doesn't count, then it's probably either Lost Odyssey or Alan Wake. The former because by being a very traditional turn-based RPG it ended up being one of the freshest RPG experiences of what was a very experimental gen, not to mention it was a very enjoyable tale altogether, and the later because it was a fun action-horror game with some quality line delivery (not on the level of Max Payne, but almost there) and an awkward yet interesting progression through the levels.

EDIT: shout-out to Fable 2. One of the most unique action/adventure RPGs ever made!