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I was thinking about this. We know Robert Downey Jr. is ready to retire so I could see Avengers 4 being his last film especially after his chat with Doctor Strange. It would be weird to see Ruffalo now out before his solo film debut, though I guess there’s already a canon Hulk film. And I can’t see either of the Chrises stepping away permanently - I’d expect they’d both do more lowkey roles and then reprise their characters every three or four years for at least a little while.