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The very first Legendary weapon I found in Borderlands (it was like a level 15) and it just incinerated people.  I used it forever.  I was playing Lilith and it was perfect with her elemental skills.  

In Borderlands 2, I LOVED the Hornet.  It was a corrosive weapon with splash damage.  You shoot one robot in a group and soon they're all melting.  It was a burst fire weapon when zoomed.  Robots are the main enemy in that game and it made them cake.

The Problem Solver in Fallout 4 is just a beast.  Every hit on an enemy adds more and more damage.  You mod it for automatic and nothing in the game can stand up to steady fire.  It's so powerful that I don't use it unless I'm in a desperate situation.