I think Prime will take the cake if it's reasonably well received. As long as it isn't generally hated I think this is a shoe in honestly.
Animal Crossing would almost be a guarantee for me as well.
Pokemon is iffy as you said. Beating RGB would be a crazy feat but being on a home console gives it a chance for sure. They really want the 2018 release date for this so that is can sell for the majority of the consoles lifetime.
I don't quite think it will reach it but I think between 25M-30M would be legit.