https://answers.microsoft.com/en-us/windows/forum/windows_10-files-winpc/cant-delete-folder-from-desktop/843f6a37-f504-41ae-b017-ec06c41b7188?auth=1
could try that, basically use task manager to kill all the tasks you can including anything to do with office if that's where these have come from, then run the command under administrator to take full control of all folders on the desktop and delete them.
However.... I would not actually advise doing that at all, I would suggest putting your desktop to a normal size and ignoring the folders existence until you actually figure out what program has made them, it's very likely if they're protected system files and backups (which is what they look like) then some thing like system restore or indeed a backup part of office has generated the folders there in error but would need them to remain there in order to work correctly, if they're not in the way (and they shouldn't be if they weren't scaled to such a huge amount) you would really be better off to leave them be.
Why not check me out on youtube and help me on the way to 2k subs over at www.youtube.com/stormcloudlive
