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Nintendo seems to work under the idea that certain creators have control over certain characters, franchises and such.

Metroid Prime is considered by Nintendo to be a sub franchise of the main Metroid one, which focuses on the side scrolling exploration. A new Prime game can be called any thing but calling it Metroid Prime 4 makes it clear this is meant to be part of the main and more or less beloved Metriod Prime lineage that everyone constantly asks about since Other M dropped the ball so spectacularly.