I think it mixed would work best
Side by side if the game can work without being verticle, Wii U styled if the bottom screen is not important, and vertical if the touch screen is needed or the game needs to be vertical.
If the Switch is vertical, you can still detach the joycons and play with the screen propped up
NintenDomination [May 2015 - July 2017]

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NintenDomination [2015/05/19 - 2017/07/02]
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