Xenoblade, and it's not even made by Nintendo (EPD, formerly EAD)! Splatoon and ARMS are the biggest original things that the company has made since Pikmin, but I feel it still needs to make something as ambitious as Mario and Zelda games.
My bet with The_Liquid_Laser: I think the Switch won't surpass the PS2 as the best selling system of all time. If it does, I'll play a game of a list that The_Liquid_Laser will provide, I will have to play it for 50 hours or complete it, whatever comes first.