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VGPolyglot said:
Umm, Destroy All Humans, I guess? They're not really heroic,but they're the protagonists.

Has there ever been an eroge that tries to make you feel guilty for playing it?

Plague inc. gives you the task of obliterating the human race with a virus. You are given methods to help it spread, and must evolve it to slow down the chances of a vaccine being created. 

 

If you kill every human before a cure is created, you win. If a cure is found, you lose.