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Unlikely to happen, perhaps a new mario game on the DS though (NSMB was a throw back to the old days and Super Mario 64 DS was a port).

It's possible if the Wii is still Nintendo's premier platform for another 5 or 6 years, because it was 6 between Mario 64 and Mario Sunshine (96-02) and 5 between Sunshine and Galaxy (02-07), so I guess it depends on how long you all expect the Wii to last for. I wouldn't expect it to last much longer considering it's a fad though..................................... (kidding)