It would be really interesting if they went with a Enders Game story where the humans can no longer be trusted and Ellies virus has evolved whereby she can communicate with the clickers.
The game is centered around an older Ellie and a Clicker who go out looking for a cure which grows somewhere in South America. She has to fight off humans and a new set of enemies, the pure breed hosts which are a tribal human / clicker type of super human that have learnt to control the virus.
The story flashes back into how the virus was supposed to have been used by a arms manufacturer to create a super soldier but it went wrong when a blackmarket deal went wrong.
The natives who are have managed to control the virus want mankind to fail for taking what they consider was a god given power and right to them and messing with power they couldn't control.
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