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I will echo a few others in the thread and say Walking Dead Season 1 got me the closest to full on crying.  I have teared up in a few instances throughout gaming:

 

FFVI Opera House scene.  My favorite scene in all of gaming.  Hit all the right notes for me at a young age.

Bioshock Infinite's ending

Batman Arkham Knight had me tearing up with nostalgia toward the end when Conroy did the iconic "I am vengeance ..." line.