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This is both difficult and easy for me. Difficult because Nintendo owns the plurality of all-time great franchises, but easy because I'm madly in love with Zelda.

Zelda's not only the best Nintendo franchise, it's the best franchise period. Over 30 years it's turned out masterpiece after masterpiece. Super Mario is a close second, and Metroid a comfortable third. Mario Kart and Donkey Kong are up there too.